Hankenson #3 - ExtracellularMatrix...

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Extracellular Matrix Kurt D. Hankenson, D.V.M., Ph.D. Orthopaedic Research Laboratories kdhank@umich.edu
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Extracellular Matrix DAY 1 Generalized overview Collagens Elastin DAY 2 Proteoglycans Matricellular proteins Adhesive proteins Extracellular enzymes DAY 3 Cell adhesion molecules Mechanical transduction Specialized structures
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Extracellular Matrix Wednesday’s highlights Elastin Proteoglycans Adhesive proteins Matricellular proteins Extracellular enzymes
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Extracellular Matrix Cell-ECM Interactions How does this occur? Criteria: » Matrix receptor Transmembrane protein Links the matrix to the cell’s cytoskeleton
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Extracellular Matrix Cell-ECM Interactions Integrins Syndecan CD44 (hylauronate receptor) CD36 (collagen/thrombospondin receptor) CD47 (integrin associated protein)
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Extracellular Matrix Cell-ECM Interactions Integrins » Principal receptors on animal cells for binding ECM proteins » Transmembrane linker proteins Collagen Fibronectin Laminin
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Extracellular Matrix Integrins Low affinity ligand binding Present in high concentration on the cell surface » Allows simultaneous binding to a large number of ECM molecules » Weak interactions “Velcro principle”
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Extracellular Matrix Integrins Transmembrane glycoproteins Alpha and beta subunits Cytoplasmic tail
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Extracellular Matrix Integrins Transmembrane glycoproteins Alpha and beta subunits Cytoplasmic tail Multiple alpha and beta chains can combine to form many functional integrins
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Extracellular Matrix Integrins » Crucial for morphogenesis and developmental processes Vasculogenesis Patterning Apical ectomdermal ridge Cavitation budding
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De Arcangelis and Georges-Labouesse, 2001
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Extracellular Matrix Integrins » Also involved in non- developmental processes Healing Remodeling Maintenance of tissue structure and function
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De Arcangelis and Georges-Labouesse, 2001
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Extracellular Matrix Integrins: attach to the ECM via RGD motifs
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Hankenson #3 - ExtracellularMatrix...

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