07MultiEnzymeSystems - Enzyme Networks Multi-Enzyme Systems...

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Enzyme Networks ? Multi-Enzyme Systems Feedback Inhibition Pattern formation – Diffusion Threshold Cell Signaling – Ligand independent lateral propagation of EGF signals
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Network Network – Emergent properties Emergent properties Complex Adaptive System Fitness to Environment Emergent Properties Fitness Biofilm Bacteria Fitness School Fish Culture/Society Epidemics/Trends New York City People Cognitive Brain Neurons Synchronized Beat Heart Cardiomyocytes Body 300 Cell Types 10 6 Genes Individual Units Adaptive Interactive Network Dynamic Collective Properties
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Metabolic regulation in a cell Can alter E 0 Protein synthesis and degradation Can alter k cat Can alter Km Allosteric inhibitor/activator Feedback inhibition G proteins Post-translational modification Receptor tyrosine kinases Feedback Inhibition Inhibition by product Of later reaction in Multi-enzyme pathways Cells have to produce When they need it The amount then need
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Butterfly Bone Bone Pattern Pattern Formation Pattern Formation How 1-D DNA to 3-D Organism? DNA CANNOT directly define macroforms Genome is Recipe, not Blueprint Cells (moves, feels, proliferates, dies) self- organize according to rules.
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