14Kla-Chemostat1 - Batch Growth - Oxygen Limitations Oxygen...

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Batch Growth - Oxygen Limitations Oxygen transfer rate (mg O 2 /liter hour) (OTR) = k L a(C* - C L ) Oxygen uptake rate (OUR) = q O2 X Under oxygen limitation, OTR = OUR (negligible maintenance requirement w.r.t. growth): () L L O X g O C C a k Y X X q OUR - = = = * 2 2 µ Which reactor gives higher productivity? Why?
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Determination of k L a Determination of k L a in a bioreactor is important in to establish its aeration efficiency and quantify effects of operating variables on oxygen supply Used to compare bioreactors before scale up or scale down A number of different methods are available Without cells growing With cells growing
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1. k L a Sulphite Oxidation Measures the rate of conversion of a 0.5m solution of sodium sulphite to sodium sulphate in the presence of a copper or cobalt catalyst Na 2 SO 3 + 1/2 O 2 2 SO 4 Cu ++ or Co ++ Oxidation of sulphite is equivalent to the oxygen-transfer rate Disadvantages i) slow, ii) effected by surface active agents iii) Rheology of soln not like media 2. k L a Gassing Out ln(C*-C L ) = -k L at + ln(C*-C 0 )
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3. k L
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This note was uploaded on 03/03/2009 for the course BIOMEDE 321 taught by Professor Takayama during the Winter '08 term at University of Michigan.

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14Kla-Chemostat1 - Batch Growth - Oxygen Limitations Oxygen...

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