16MaterialsBAlanceNetworkReview

16MaterialsBAlanceNetworkReview - Our goal is to get the...

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1 Our goal is to get the real whole picture Snake Tree trunks Wall Blanket Rope Seeing the Parts but not the Whole I know details of the components but don’t know what the whole is. (e.g. conventional biochemistry, genome)
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2 Seeing the whole from far away I could see the whole silouette but I can’t really tell much more. (e.g. anatomy of biochemical networks) SS g EE Degrades S changes S’ constant ?
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3 “g” is a gene product (black wing) Allosteric production Degrades proportional to [g] Gene production affected by [S]
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4 How can we generate sharp transitions in patterns from a concentration gradient of a chemical? How Does Receptor Density Affect Subcellular Signaling and Behavior? Sawano, Takayama, Matsuda, Miyawaki Dev. Cell 2002 Local EGF Delivery Local Signaling? Global Signaling?
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5 Local versus Global Activation of Receptor Tyrosine Kinases (RTK) Schlessinger Mol. Cell 2002 Sawano, Zhu, Takayama, Matsuda, Miyawaki Dev. Cell 2002 Local dimerization/phosphorylation Locally activated receptors trigger chain reaction Local Global Propagation + Amplification State Space and and Attractors Attractors Reynolds, Tischer, Verveer, Rocks, Bastiaen Nat Cell Biol 2003 I/R : Max PTP inh/Max PTP reactiv α 2 / α 1 RTK kinase P/RTK kinase P/K Max PTP/Max RTK
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16MaterialsBAlanceNetworkReview - Our goal is to get the...

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