18FedBatchCulture - Volume Textbook (uses total biomass X t...

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1 Both can maintain optimal specific growth rate and substrate concentrations. In Fed-Batch, effluent is not continuously removed and thus washout does not occur . Fed-Batch vs Continuous Bioreactors Fed-batch fermenters good for production of compounds produced during very slow or zero growth. In Fed-batch, the feed does not need to contain all the nutrients needed to sustain growth. Why not? Contamination will also not have the same dramatic effect on a fed-batch fermenter. Why not? Rationale for Fed-Batch Cultivation
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2 Fed batch reactor Biomass Balance Substrate Balance Product Balance (Growth Associated Product)
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Unformatted text preview: Volume Textbook (uses total biomass X t ) Biomass Balance can maintain optimal specific growth rate and substrate concentrations At quasi-steady-state (nutrient consumption ~ feed rate) So, just like with chemostats 3 Textbook (uses total biomass X t ) At quasi-steady-state ( X t ~ VX m ; X m is max X; also dX/dt = 0) So from Integration yields As we are now very familiar, At quasi-steady-state, assume S ~ 0 Total X would be times volume Textbook (uses total biomass X t ) Product Balance Substituting for X t Integration yields Product concentration 4 5...
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18FedBatchCulture - Volume Textbook (uses total biomass X t...

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