19ScalingBasicIntro - Scaling Scale up Scale down What does...

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Scaling Scale up Scale down What does it mean for bioreactions? Basics of scaling Fluid flow, Diffusion, and Mixing Concentrations, Sensing Sterilization Scale-Up Problem A scale-up problem is something that we do not see in a small scale experiment and are disappointed to find in a large-scale experiment Relative Cost of Changes Pre-design phase 1 Design phase 10 Construction phase 100 Plant in operation 1000
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Scale-Down Problem/Opportunity Fluid flow characteristics, mixing, chemical depletion/accumulation, temperature/chemical gradients, sterilization. Use as models to optimize large bioreactors Unique opportunities
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Scaling and Fluid Flows Scaling and Fluid Flows - Surface Surface -to to -Volume Ratio Volume Ratio - Scaling 1 1 1 1/10 1/100 1/1000 1/100 1/100 1/100 1/10,000 1/10,000 1,000,000 1,000,000 1/1000 1/1000 1/10 1/10 6 1/10 1/10 9 Area = (Length) 2 Volume = (Length) 3 Length Length Area Volume Area Volume
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This note was uploaded on 03/03/2009 for the course BIOMEDE 321 taught by Professor Takayama during the Winter '08 term at University of Michigan.

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19ScalingBasicIntro - Scaling Scale up Scale down What does...

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