19ScalingBasicIntro - Scaling Scale up Scale down What does...

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Scaling Scale up Scale down What does it mean for bioreactions? Basics of scaling Fluid flow, Diffusion, and Mixing Concentrations, Sensing Sterilization Scale-Up Problem A scale-up problem is something that we do not see in a small scale experiment and are disappointed to find in a large-scale experiment Relative Cost of Changes Pre-design phase 1 Design phase 10 Construction phase 100 Plant in operation 1000
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Scale-Down Problem/Opportunity Fluid flow characteristics, mixing, chemical depletion/accumulation, temperature/chemical gradients, sterilization. Use as models to optimize large bioreactors Unique opportunities
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Scaling and Fluid Flows Scaling and Fluid Flows - Surface Surface- to to- Volume Ratio Volume Ratio - Scaling 1 1 1 1 1 1/10 1/10 1/100 1/1000 1/100 1/1000 1/100 1/100 1/10,000 1/10,000 1,000,000 1,000,000 1/1000 1/1000 1/10 1/10 6 1/10 1/10 9 Area = (Length) 2 Volume = (Length) 3 Length Length Area Volume Area Volume
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Strength/Weight Strength cross-sectional area L 2 Weight
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  • Winter '08
  • Takayama
  • Fluid Dynamics, scaling laws, scaling Fluid flow, Conventional Scaling Laws

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