{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

CH 10 - Chapter 10 Gene Expression and Regulation 0...

Info icon This preview shows pages 1–8. Sign up to view the full content.

View Full Document Right Arrow Icon
Chapter 10: Gene Expression and Regulation 0
Image of page 1

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Marvelous Mussel Adhesive Marine mussel (mytilus californicus) manufactures ultimate underwater adhesive. Called “byssus”: specialized type of protein Mussel binds itself to rocks w/ threads coated with byssus. Gene for byssus has been put into yeast Yeast synthesize the protein based on the instructions in the mussel DNA. So how can we remove the gene from 1 organism and have it expressed in a completely different organism? 0
Image of page 2
Same 2 steps produce all protiens: 1) DNA is “transcrbed” to form RNA. occurs in the nucleus. RNA moves into the cytoplasm. 2) RNA is “translated” to form polypeptide chains, which fold to form proteins Steps from DNA to Proteins “Central Dogma of Molecular Biology” 0 DNA Proteins RNA Transcri ption Tran slatio n
Image of page 3

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
The Linkage Between DNA and Protein DNA contains the molecular blueprint of every cell Proteins are the “molecular workers” of the cell Proteins control cell shape, function, reproduction, and synthesis of biomolecules The information in DNA genes must therefore be linked to the proteins that run the cell
Image of page 4
How Are Genes and Proteins Related? Gene: segment of DNA located at a particular place on a chromosome DNA can code for: 1. A specific amino acid sequence in a protein 2. The RNA to help make proteins Gene → Protein or RNA to make protein 0
Image of page 5

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Most Genes Contain the Information for the Synthesis of a Single Protein Synthesis of new molecules inside the cell occurs through biochemical pathways Each step in a biochemical pathway is catalyzed by a protein enzyme George Beadle and Edward Tatum showed that “one DNA gene encodes the information for one enzyme (protein) in a biochemical pathway”
Image of page 6
Supplements Added to Medium none Normal Neurospora ornithine enzyme 1 gene B gene A enzyme 2 arginine amino acid needed in protein synthesis citrulline Growth characteristics of normal and mutant Neurospora on simple medium with different supplements show that defects in a single gene lead to defects in a single enzyme. The biochemical pathway for synthesis of the amino acid arginine involves two steps, each catalyzed by a different enzyme. Normal Neurospora can synthesize arginine, citrulline, and ornithine. Conclusions Mutant A grows only if arginine is added. It cannot synthesize arginine because it has a defect in enzyme 2; gene A is needed for synthesis of arginine.
Image of page 7

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 8
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern