Final Review - Review Materials for the Final Exam(not nd...

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Review Materials for the Final Exam (not cumulative) on CH 12 (2 nd half), CH 13, and CH 14 Use the web site below for review questions:
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CH 12 (second half) CH 12 (second half) PICTURES PICTURES
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0
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0 Karyotype.swf (use Apple Quicktime to open and view)
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Complete Linkage x AB ab 50% AB 50% ab All AaBb meiosis, gamete formation Parents: F 1 offspring: Equal ratios of two types of gametes: A B a b A B a b a b A B 0
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Incomplete Linkage Parents: F 1 offspring: Unequal ratios of four types of gametes: All AaCc x meiosis, gamete formation AC ac A C A C A C a c a c A c a C a c 85% parental genotypes 15% recombinant genotypes 0
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Crossover Frequency Proportional to the distance that separates genes A B C D
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Pedigree Symbols
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Pedigree for Polydactyly I II III IV V 5,5 6,6 5,5 6,6 5,5 6,6 5,5 6,6 5,5 6,6 5,5 6,6 6,6 5,5 6,6 5,5 5,6 6,7 6,6 6,6 male female Black = # fingers Blue = # toes
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Autosomal Recessive Inheritance Patterns If parents are both heterozygous, child will have a 25% chance of being affected 0
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0 Autosomal recessive.swf (use Apple Quicktime to open and view)
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Galactosemia Caused by autosomal recessive allele Gene specifies a mutant enzyme in the pathway that breaks down lactose So, can’t convert lactose completely = problems galactose-1- phosphate enzyme 2 lactose galactose enzyme 1 + glucose glucose-1- phosphate enzyme 3 intermediate in glycolysis 0
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Autosomal Dominant Inheritance Trait typically appears in every generation If one parent is heterozygous (diseased), child will have a 50% chance of being affected 0
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0 Autosomal dominant.swf (use Apple Quicktime to open and view)
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X-Linked Recessive Inheritance Males show disorder more than females Son cannot inherit disorder from his father (why?)
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0 X-linked recessive.swf (use Apple Quicktime to open and view)
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XY XX = disease allele = diseased phenotype = male = female Types of disease transmission
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X X XY marries P 1 F 1 X X X XX X Y Y F 2 Results depend on which 2 individuals mate
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X X marries P 1 F 1 X X X XX X Y Y F 2 XY X X XX X Y XY
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X X marries P 1 F 1 X X Y Y F 2 XY XX X Y XY XX X X X X
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  • Spring '08
  • Minor
  • DNA

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