Midterm 1. Study Guide - Study guide for the first midterm...

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2n Replication (interphase) 2nx2 mitosis 2n 2n cytokinesis 2n 2n 2n replication 2nx2 Meiosis 1 1nx2 1nx2 Meiosis 2 1n 1n 1n 1n Study guide for the first midterm exam, BME/BIO 80H, The Human Genome From lecture 1 1. Pre-Mendel ideas on  gene transmission: Hippocrates, Aristotle, Preformation, Lamarck, Weismann a. Hippocrates: All parts of the body produce substances called humors that get clleced together to provide  the material for heredity. Humors from the male and female were blended to produce the offspring.  b. Aristotle (he argued against Hippocrates’ ideas Loss of body parts is not inherited Sometimes people look more like distant relatives Traits disappear and reappear  c. Preformation Preformed people, “spermastic or “ovistic” d. Lamarck  (doctrine of inheritance of acquired characteristics) Traits are modified then passed on to offspring Materials are gemmuals like humers Darwin suggested gemmules can enter a dormant state e. Weismann shows that acquired traits are not inherited (experiments with mice) Two ice with tails cut off do not produce mice without tails He did this for 20 generations Put to rest the doctrine of inheritance of acquired traits  2. Significance of  Mendel’s findings a. Led to laws o heredity b. His experiments in pea plant revealed how a trait is passed through the inheritance of “factors”  3. Definition of species a. Ernst Mayr's definition of a species as "groups of actually or potentially interbreeding natural  populations, which are reproductively isolated from other such groups 4. Mendel’s successors  (from handout; be able to match the name to the contribution/finding) a. 1869: Johann Friedrich Miescher: isolated DNA first from white blood cells in Human Puss and  later from salmon sperm cells, discovery of nucleic acit  b. 1882-1885: Flemming and Strasburger: recognize chromosomes, Van Beneden: describes  meiosis, separation of chromosomes to daughter cells c. 1902 Walter Sutton: Proposed the Chromosome Theory (“Factors located on chromosomes  and by segregation of pairs of similar chromosomes, are transmitted to the daughter cells in the  manner in accord with mendel’s law of inheritance” d. 1900-1920: T.H. morgan and Sturtevant performed chromosome mapping. Found sex linked  inheritance e. 1943 Beadle and Tatum: one gene one enzyme, each gene produces a particular substance f. 1944: Oswald Avery: showed that DNA not protein stores the genetic information g. 1940s Barbara McClintock jumping gnes that can change location on chromosomes
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  • Spring '09
  • Rothwel
  • Cell Cycle, a. b. c., b. c. d., C. D. E., a. Mendel, b. i. ii.

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