Question Edward Leonard’s groups proposal of a membraneless filtration or dialysis system seems fairly feasible. Their system involves a fluidic filtration system whereby a stream of blood is surrounded by streams of dialysate flowing at the same rates as the stream of blood. This results in the particulates continuing along their original flow path and solutes diffusing from blood to dialysate. Leonard’s group has modeled the behavior of blood and proteins in this fluidic system and shown that it is very feasible to develop a dialysis method based off of this system. The only hang ups that the method could potentially have come from how to separate the blood from the dialysate after filtration and how to remove the macromolecules from the dialysate. This must be done in order to avoid the equilibration state of the macromolecules that would eventually result between the dialysate and the blood. These two issues are possible to overcome. The first issue can be resolved by a simple physical separation of the flows after filtration. The second
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This note was uploaded on 03/08/2009 for the course BME 131 taught by Professor -2 during the Spring '08 term at Cornell.