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Unformatted text preview: reliant on other mechanism of transmission. Current knowledge is that prions are transmitted through ingestion of meat and other bodily fluids. Once in the body of the host they travel through the blood stream to reach their target: the brain. Also prions are suspected to remain in infected bodies urine, saliva, and other bodily fluids once removed from the host. Transmissions can then occur through these fluids in the environment. The prions enter the host cell and begin self replication through the PrPc, PrPsc complex. When the prions build up in the host cells they become insoluble plaques known as amyloids. The amyloids presumable burst the cell and form a characteristic spongy texture in the infected tissue....
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This note was uploaded on 03/09/2009 for the course BIO 2900 taught by Professor Ghiorse during the Fall '07 term at Cornell University (Engineering School).
- Fall '07