ProblemSet7_b - BICD100 Genetics Fall 2005 Prof Reinagel...

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BICD100 Genetics Fall 2005 Prof. Reinagel Problem Set 7 = Practice Midterm 2 This is version b (Problem 6 error corrected) MT2 will cover: -basic forward genetics (from lecture on Oct 11) -meiosis, chromosomal segregation, and nondisjunction -recombination frequencies in ordinary eukaryotes (eg. peas, flies, mice) -deriving genetic maps of multiple genes from recombination frequencies -three factor crosses and interference -mapping in unordered tetrads (yeast), including centromere mapping -mapping in ordered tetrads, including centromere mapping MT2 will NOT cover bacteriophage genetics, deletion mapping, or bacterial mapping with Hfr strains. (These will be tested on the final exam). DISCLAIMER: These questions are typical of the types of problems you would encounter on an exam. No single exam can test every topic that you are responsible for, so these questions do not exhaustively cover all the possible types of questions you could be asked. The types of problems asked on the problem sets are also typical exam problems. The number of questions depends on the length of the questions.
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BICD100 Genetics Fall 2005 Prof. Reinagel 1. You are studying three autosomal recessive mutations in Drosophila that are linked: mangy, nervous, and ornery. You obtain flies from a pure breeding mangy, nervous, and ornery strain and cross to wild type flies to obtain an F1. You then cross the F1 flies to flies from the pure breeding mangy, nervous, and ornery strain to obtain the following F2: Phenotype Number of F2 flies mangy, nervous, ornery 2119 mangy, nervous 3 mangy, ornery 342 nervous, ornery 20 mangy 23 nervous 351 ornery 4 wild type 2138 Derive the most accurate map you can of the order of these genes and the distances between them.
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BICD100 Genetics Fall 2005 Prof. Reinagel 2. You cross two haploid yeast strains cdc10 leu1 trp5 X cdc+ leu+ trp+ to obtain a triply heterozygous diploid. The cdc10 gene is tightly linked the centromere of chromosome III. The leu1 and trp5 genes are both located on the same arm of chromosome VII, with leu1 closer to the centromere than trp5.
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