Lecture5-2009W - Aerobic Metabolism(1 Glycolysis(2 Krebs...

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Aerobic Metabolism (1) Glycolysis, (2) Krebs cycle (3) Electron transport chain (4) oxidative phosphorylation Citric acid cycle = Krebs cycle ETC/OP Glycolysis aerobic vs. anaerobic Glycolysis 1. glucose barb2right 2 pyruvic acid 2. 2 NAD barb2right 2NADH2 3. net yield of 2 ATP Krebs cycle 1. 6 CO2 produced / glucose 2. 8 NADH 2 + 2 FADH 2 3. 2 ATP (through GTP) anaerobic glycolysis
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Electron Transport Chain (a series of major protein complexes in the inner memb. of Mt.) Oxidative Phosphorylation (process of forming ATP using energy released from ETC) P/O ratio (NADH2=3, FADH2=2) NAD & FAD barb2right immediate electron acceptor O2 barb2right final electron acceptor b/c (1) continuous supply (2) converted into H2O, thereby carrying electrons out of cells aerobic:
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Unformatted text preview: aerobic: C 6 H 12 O 6 + 6O 2 b 6CO 2 + 6H 2 O (+ 38 ATP ) anaerobic: Glucose b 2 lactate + 2 ATP b aerobic, ~19x more efficient Summary: ATP production 2 ATP Efficiency of Aerobic metabolism C 6 H 12 O 6 + 38Pi + 38ADP +6O 2 bb 6CO 2 + 6H 2 O + 38ATP h Δ Gº = -686kcal/mol of glucose h Heat E = -420 kcal/mol h Net E for ATP synthesis: 266 kcal/mol 1 mole of ATP: 7 kcal ( 266/38) Efficiency: if all E glucose converted to ATP, 686/7 = 98 ATP but only 38 ATP produced. so efficiency is ~40% (38/98 ATP) Comparative properties of ATP production mechanisms * Phosphogens * Anaerobic metabolism has advantages too! (fast, no O2 required)...
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