Lecture9-2009W - Passive transport(B Facilitated passive...

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Passive transport: (B) Facilitated passive transport checkbld Protein pores / channels - ionophores checkbld Carrier-mediated - uniporters - coupled transporters (i) symporters (ii) antiporters Active transport: up-hill transport Basic properties: (1) carrier-mediated (2) metabolism energy required barb2right sensitive to respiratory poisons & oxygen deficiency (3) create a voltage difference barb2right electroneutral vs. electrogenic (4) examples barb2right Na + -K + ATPase (pump), the best-known barb2right Ca 2+ ATPasein the SR of muscle barb2right H + -K + ATPase in stomach barb2right H + ATPase in gills and kidneys
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1. Primary active transport: barb2right transporter = ATPase barb2right e.g. Na + -K + ATPase 2. Secondary active transport: barb2right immediate energy source = electrochemical gradient (not ATP) barb2right cotransporters vs. countertransporters Ionic gradient as a source of Energy barb2right Energy release occurs when the ions are allowed to flow down their gradient across the membrane 1. Production of electrical signals e.g. Na +
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