Lecture14-2009W - Activation, inactivation, closing depol....

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Voltage-gated Na + channel Puffer fish Tetrodotoxin (TTX) , specific blocker of sodium channels c 100 -500 Na channels / μ m 2 , very small fraction of the total surface area c Unitary current – 10M ions / sec c Na selectivity c Voltage-dependent gating: Sliding helix c Positive-feedback loop (Hodgkin cycle) Sodium channel gating:
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Unformatted text preview: Activation, inactivation, closing depol. Voltage-gated K + channel -falling phase of AP-slowly activating-several subtypes Summary: ionic basis of action potentials K current Na current Feedback cycles responsible for V m changes during an AP Negative FB Positive FB...
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This note was uploaded on 03/11/2009 for the course BIOS 342 taught by Professor Tanda during the Spring '09 term at Ohio University- Athens.

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Lecture14-2009W - Activation, inactivation, closing depol....

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