Lecture14-2009W - Activation inactivation closing depol...

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Voltage-gated Na + channel Puffer fish Tetrodotoxin (TTX) , specific blocker of sodium channels checkbld 100 -500 Na channels / μ m 2 , very small fraction of the total surface area checkbld Unitary current – 10M ions / sec checkbld Na selectivity checkbld Voltage-dependent gating: Sliding helix checkbld Positive-feedback loop (Hodgkin cycle)
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Unformatted text preview: Activation, inactivation, closing depol. Voltage-gated K + channel -falling phase of AP-slowly activating-several subtypes Summary: ionic basis of action potentials K current Na current Feedback cycles responsible for V m changes during an AP Negative FB Positive FB...
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