Lecture17-2009W - b (1) AP b (2) Voltage-gated Ca 2+ Ch. b...

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h Fast vs. slow chemical transmission Chemical synapse c presynaptic: c post-synaptic receptors b ionotropic Receptors (=ligand-gated ion ch.) b metabotropic R (=G-protein coupled) Ionotropic vs. metabotropic h Synaptic potentials b epps (=e ndp late p otentials) b EPSP (= e xcitatory p osts ynaptic p otential) (cf) IPSP, i nhibitory PSP Fast Chemical synapses (example) Neuromuscular junction (NMJ) b Acetylcholine, NT @ NMJ h Synaptic currents b EPSC, IPSC
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h Sequence of events of synaptic transmission at NMJ
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Unformatted text preview: b (1) AP b (2) Voltage-gated Ca 2+ Ch. b (3) NT (ACh) release b (4) AChR opening b (5) EPSP depol. memb. b (6) muscle AP contraction b (7) ACh degradation by AChE b (8) Recycle of choline h Neuronal synaptic potentials resemble those @ NMJ (1) Excitatory CNS synapse: glutamate in mammalian CNS (2) Inhibitory CNS synapse: GABA (gamma aminobutyric acid) a. excitatory NT receptors- Na+, K+ ions b. inhibitory NT receptors- Cl- ions...
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This note was uploaded on 03/11/2009 for the course BIOS 342 taught by Professor Tanda during the Spring '09 term at Ohio University- Athens.

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Lecture17-2009W - b (1) AP b (2) Voltage-gated Ca 2+ Ch. b...

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