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Lecture17-2009W - b(1 AP b(2 Voltage-gated Ca 2 Ch b(3...

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head2right Fast vs. slow chemical transmission Chemical synapse checkbld presynaptic: synaptic vesicles & NT release checkbld post-synaptic receptors barb2right ionotropic Receptors (=ligand-gated ion ch.) barb2right metabotropic R (=G-protein coupled) Ionotropic vs. metabotropic head2right Synaptic potentials barb2right epps (=e ndp late p otentials) barb2right EPSP (= e xcitatory p osts ynaptic p otential) (cf) IPSP, i nhibitory PSP Fast Chemical synapses (example) Neuromuscular junction (NMJ) barb2right Acetylcholine, NT @ NMJ head2right Synaptic currents barb2right EPSC, IPSC
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head2right Sequence of events of synaptic transmission at NMJ
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Unformatted text preview: b (1) AP b (2) Voltage-gated Ca 2+ Ch. b (3) NT (ACh) release b (4) AChR opening b (5) EPSP – depol. memb. b (6) muscle AP – contraction b (7) ACh degradation by AChE b (8) Recycle of choline h Neuronal synaptic potentials resemble those @ NMJ (1) Excitatory CNS synapse: glutamate in mammalian CNS (2) Inhibitory CNS synapse: GABA (gamma aminobutyric acid) a. excitatory NT receptors- Na+, K+ ions b. inhibitory NT receptors- Cl- ions...
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  • Spring '09
  • Tanda
  • synaptic potentials, receptors Ionotropic Receptors, excitatory NT receptors, inhibitory NT receptors, Excitatory CNS synapse

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