Lecture18-2009W - (1) Neurotransmitters (e.g.) ACh -...

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(1) NTs: Presynaptic release of Neurotransmitters (1) Exogeneous appl. of the candidate NT the same physiol. effects (2) Must be released when the presynaptic neuron is active (3) Must be blocked by the same agents that block the same transmission Termination of NT signaling (1) Enzymatic degradation (2) Reuptake (3) Enzymatic modification + (4) NT Receptor decsensitaiz .
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(2) Voltage- and Ca 2+ -dependent depolarization Depolarization-release coupled (3a) Quantal release of NT miniature depolarization (~0.4mV in amp.) miniature endplate potentials (mepps) Evoked miniature EPSCs are quantal Blockers TTX - Na Ch. TEA - K Ch. (TEA= tetraethyl ammonium) [Ca 2+ ] ext -dependent NT release Quanta = multi-molecular packet
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Unformatted text preview: (1) Neurotransmitters (e.g.) ACh - synthesized and stored in the presynaptic terminal (2) Voltage- and Ca 2+-dependent (3) Quantal & vesicular (4) Synaptic vesicle recycling (3b) Vesicular release of NT a. targeting b. docking c. Ca 2+ entry d. fusion trivial: How does BOTOX work? (4) Synaptic vesicle recylcling a. classical, clathrin-mediated vs. b. kiss-and-run Thank you for trying deskUNPDF. This free trial is limited to one page conversions for the purpose of evaluating deskUNPDF’s capabilities. If you wish to obtain unrestricted functionality in deskUNPDF, please visit www.docudesk.com to purchase or learn more about our PDF software solutions....
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This note was uploaded on 03/11/2009 for the course BIOS 342 taught by Professor Tanda during the Spring '09 term at Ohio University- Athens.

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Lecture18-2009W - (1) Neurotransmitters (e.g.) ACh -...

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