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Lecture18-2009W - depolarization Blockers TTX Na Ch TEA K...

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Presynaptic release of Neurotransmitters (1) Neurotransmitters (e.g.) ACh - synthesized and stored in the presynaptic terminal (2) Voltage- and Ca 2+ -dependent (3) Quantal & vesicular (4) Synaptic vesicle recycling (1) NTs: (1) Exogeneous appl. of the candidate NT barb2right the same physiol. effects (2) Must be released when the presynaptic neuron is active (3) Must be blocked by the same agents that block the same transmission Fast, direct Slow, indirect head2right Termination of NT signaling (1) Enzymatic degradation (2) Reuptake (3) Enzymatic modification + (4) NT Receptor decsensitaiz.
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(2) Voltage- and Ca 2+ -dependent barb2right Katz & Miledi (late 60’s)
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Unformatted text preview: depolarization Blockers TTX - Na Ch. TEA - K Ch. b [Ca 2+ ] ext-dependent NT release b Depolarization-release coupled (TEA= tetraethyl ammonium) (3a) Quantal release of NT b Paul Fatt & Bernard Katz (1952) b miniature depolarization (~0.4mV in amp.) b miniature endplate potentials (mepps) c Evoked miniature EPSCs are quantal s Quanta = multi-molecular packet (3b) Vesicular release of NT trivial: How does BOTOX work? a. targeting b. docking c. Ca 2+ entry d. fusion (4) Synaptic vesicle recylcling a. classical, clathrin-mediated vs. b. kiss-and-run...
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