Lecture18-2009W - depolarization Blockers TTX - Na Ch. TEA...

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Presynaptic release of Neurotransmitters (1) Neurotransmitters (e.g.) ACh - synthesized and stored in the presynaptic terminal (2) Voltage- and Ca 2+ -dependent (4) Synaptic vesicle recycling (1) NTs: (1) Exogeneous appl. of the candidate NT b the same physiol. effects (2) Must be released when the presynaptic neuron is active (3) Must be blocked by the same agents that block the same transmission Fast, direct Slow, indirect h Termination of NT signaling (1) Enzymatic degradation (2) Reuptake (3) Enzymatic modification + (4) NT Receptor decsensitaiz.
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(2) Voltage- and Ca 2+ -dependent b
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Unformatted text preview: depolarization Blockers TTX - Na Ch. TEA - K Ch. b [Ca 2+ ] ext-dependent NT release b Depolarization-release coupled (TEA= tetraethyl ammonium) (3a) Quantal release of NT b Paul Fatt & Bernard Katz (1952) b miniature depolarization (~0.4mV in amp.) b miniature endplate potentials (mepps) c Evoked miniature EPSCs are quantal s Quanta = multi-molecular packet (3b) Vesicular release of NT trivial: How does BOTOX work? a. targeting b. docking c. Ca 2+ entry d. fusion (4) Synaptic vesicle recylcling a. classical, clathrin-mediated vs. b. kiss-and-run...
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This note was uploaded on 03/11/2009 for the course BIOS 342 taught by Professor Tanda during the Spring '09 term at Ohio University- Athens.

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Lecture18-2009W - depolarization Blockers TTX - Na Ch. TEA...

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