Lecture18-2009W - depolarization Blockers TTX Na Ch TEA K...

Info icon This preview shows pages 1–3. Sign up to view the full content.

View Full Document Right Arrow Icon
Presynaptic release of Neurotransmitters (1) Neurotransmitters (e.g.) ACh - synthesized and stored in the presynaptic terminal (2) Voltage- and Ca 2+ -dependent (3) Quantal & vesicular (4) Synaptic vesicle recycling (1) NTs: (1) Exogeneous appl. of the candidate NT barb2right the same physiol. effects (2) Must be released when the presynaptic neuron is active (3) Must be blocked by the same agents that block the same transmission Fast, direct Slow, indirect head2right Termination of NT signaling (1) Enzymatic degradation (2) Reuptake (3) Enzymatic modification + (4) NT Receptor decsensitaiz.
Image of page 1

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
(2) Voltage- and Ca 2+ -dependent barb2right Katz & Miledi (late 60’s)
Image of page 2
Image of page 3
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: depolarization Blockers TTX - Na Ch. TEA - K Ch. b [Ca 2+ ] ext-dependent NT release b Depolarization-release coupled (TEA= tetraethyl ammonium) (3a) Quantal release of NT b Paul Fatt & Bernard Katz (1952) b miniature depolarization (~0.4mV in amp.) b miniature endplate potentials (mepps) c Evoked miniature EPSCs are quantal s Quanta = multi-molecular packet (3b) Vesicular release of NT trivial: How does BOTOX work? a. targeting b. docking c. Ca 2+ entry d. fusion (4) Synaptic vesicle recylcling a. classical, clathrin-mediated vs. b. kiss-and-run...
View Full Document

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern