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Unformatted text preview: depolarization Blockers TTX - Na Ch. TEA - K Ch. b [Ca 2+ ] ext-dependent NT release b Depolarization-release coupled (TEA= tetraethyl ammonium) (3a) Quantal release of NT b Paul Fatt & Bernard Katz (1952) b miniature depolarization (~0.4mV in amp.) b miniature endplate potentials (mepps) c Evoked miniature EPSCs are quantal s Quanta = multi-molecular packet (3b) Vesicular release of NT trivial: How does BOTOX work? a. targeting b. docking c. Ca 2+ entry d. fusion (4) Synaptic vesicle recylcling a. classical, clathrin-mediated vs. b. kiss-and-run...
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This note was uploaded on 03/11/2009 for the course BIOS 342 taught by Professor Tanda during the Spring '09 term at Ohio University- Athens.
- Spring '09