Lecture20-2009W - Integration at synapses In general each...

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Integration at synapses In general, each neuron has more than one synaptic contact Spatial summation vs. Temporal summation Spatial summation Temporal summation
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head2right NT receptors for slow, metabotropic actions: < G-protein-mediated synaptic transmission > e.g. Muscarinic AChRs cf) nicotinic AChRs Cell function xrhombus G proteins in postsynaptic cells act via intracellular effectors 1. NT can mediate different synaptic effects by activating different kinds of receptors 2. G protein: membrane-delimited action 3. Ion channels can be gated by signals other than voltage or ligands xrhombus G proteins can act via non-cAMP signaling pathway 1. cyclic GMP 2. IP 3 & DAG 3. Ca 2+ ions barb2right calmodulin
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Unformatted text preview: 3. Ca 2+ ions b calmodulin b CaM kinase Synaptic plasticity b changes in synaptic strength How? Increase of presynaptic Ca 2+ 1. Short-Term Homosynaptic Modulation 2. Heterosynaptic Modulation (e.g. Aplysia californica (Dr. E. Kandel) b Gill withdrawal reflex -sensitization Tail Facilitatory neuron Before Training After c Simple form of learning Mechanism? 3. Long-Term Potentiation (LTP): Cellular Model of Learning & Memory h Induction: NMDA receptor-dependent h Maintenance: Ca 2+-dependent second messenger pathways b increase of GluR sensitivity h Retrograde signal b increase of NT release Before LTP...
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  • Spring '09
  • Tanda
  • NMDA, Spatial Summation, temporal summation, Spatial summation vs, different synaptic effects

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