Lecture20-2009W - 3. Ca 2+ ions b calmodulin b CaM kinase...

Info iconThis preview shows pages 1–4. Sign up to view the full content.

View Full Document Right Arrow Icon
Integration at synapses In general, each neuron has more than one synaptic contact Spatial summation vs. Temporal summation Spatial summation Temporal summation
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
h NT receptors for slow, metabotropic actions: < G-protein-mediated synaptic transmission > e.g. Muscarinic AChRs cf) nicotinic AChRs Cell function x G proteins in postsynaptic cells act via intracellular effectors 1. NT can mediate different synaptic effects by activating different kinds of receptors 2. G protein: membrane-delimited action 3. Ion channels can be gated by signals other than voltage or ligands x G proteins can act via non-cAMP signaling pathway 1. cyclic GMP 2. IP 3
Background image of page 2
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 4
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: 3. Ca 2+ ions b calmodulin b CaM kinase Synaptic plasticity b changes in synaptic strength How? Increase of presynaptic Ca 2+ 1. Short-Term Homosynaptic Modulation 2. Heterosynaptic Modulation (e.g. Aplysia californica (Dr. E. Kandel) b Gill withdrawal reflex -sensitization Tail Facilitatory neuron Before Training After c Simple form of learning Mechanism? 3. Long-Term Potentiation (LTP): Cellular Model of Learning &amp; Memory h Induction: NMDA receptor-dependent h Maintenance: Ca 2+-dependent second messenger pathways b increase of GluR sensitivity h Retrograde signal b increase of NT release Before LTP...
View Full Document

This note was uploaded on 03/11/2009 for the course BIOS 342 taught by Professor Tanda during the Spring '09 term at Ohio University- Athens.

Page1 / 4

Lecture20-2009W - 3. Ca 2+ ions b calmodulin b CaM kinase...

This preview shows document pages 1 - 4. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online