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Citric_Acid_Cycle_figures - OXIDATIVE CITRIC ACID CYCLE...

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Unformatted text preview: OXIDATIVE CITRIC ACID CYCLE PHOSPHORYLATION Fatty acids Acetyl CoA Glucose Matrix Amino acids Proton . Inner . Electron-transport gradient mltochonclrlal chain (~36 H+l membrane | Figure17-3 Biochemistry, Sixth Edition @ 2007 W. H.Freeman and Company TABLE IT. I Pyruvate dehydrogenase complex of E. coli Number Prosthetic Enzyme Abbreviation of chains group Reaction catalyzed Pyruvate dehydrogenase E1 24 TPP Oxidative decarboxylation component of pyruvate Dihydrolipoyl E2 24 Lipoamide Transfer of acetyl group transacetylase to CoA Dihydrolipoyl E3 12 FAD Regeneration of the dehydrogenase oxidized form of Iipoamide Table 17-1 Biochemistry, Sixth Edition © 2007 W. B. Freeman and Company Thiamine pyrophosphate (TPP) lipoic mid Umlumhered figure pg 478:: Biochemistry. Sixth Eamon e 200/ w H.Freanan and Company Pyruyate \vco2 2e' Acetyl CoA 2co2 GTP Fiwre 11-4 Biochemistry, Sixth Edition a 2007 w H Freeman and Campany 0 Acetyl coenzyme A (Acetyl Coll) unnumhuedflgum pg A75 mmnmmnmm w mlw n Freeman and (mum o coo- H_‘|: 0" “*c/ synthase C00- 'OOC—C II I Citrate | T” 92 -I- NADH + I-I+ C00- C00- NAD Oxalomotnte Isuitruto lsocitrate Malate dehydrogenase NADH + H“ NAD+ dehydrogenase 'OOC + CO; T00- \I¢° HO—C—H le éHz CH2 [salon | coo- C00- u-Kelogluinruio a-Ketoglutarate NAD'I- Fumarase dehydrogenase + CoA complex CoA—S \cflo NADH + H+ ”20 ”Kc/coo- | + co2 N f": C Succinate COO- Succinyl CoA / x 130;: I: dehydrogenase | synthetase H2 umum 0 EH2 COO— FADH; CH2 GDP + PI Siminyltol FAD I GT" COO- + CoA Siminuie Figure 1 7-1 5 Biochemistry, Sixth Edition © 2007 W. H. Freeman and Company Glucose f1 Pyruvate r Pyruvate dehydrogenase complex Acetyl CoA CO2 Lipids Figure 1 7-16 Biochemistry Sixth Edition © 2007 w. H. Freeman and Company Pyruvate _I_ 6 ATP, acetyl CoA, and NADH G) ADP and pyruvate Acetyl CoA Oxalo- \\ acetate . ’ Cltrate Malate \ t lsocitrate Fumarate 6 ATP and ‘L NADH ‘ G) ADP Succinate a-Ketoglutarate ‘ Succinyl)‘ e ATEsuccinyl A CoA,and Co NADH Figure 1 7-1 9 Biochemistry, Sixth Edition © 2007 w. H. Freeman and Company Figure 1 7.13 mmmnm smn am a 20177w n Plenum and [murmur ATP ADP A 0 Kinase Active Inactive PDH PDH w Pi H20 (A) HIGH ENERGY CHARGE (B) LOW ENERGY CHARGE Pyruvate Pyruvate NAD+ NAD+ (+3 W9 e 9 (9 N ADH NADH Acetyl CoA Acetyl CoA e ® ADP/"\A'rp ® ADP/N e- Glucose Pyruvate Other ‘ amino acids, purines, pyrimidines , Acetyl CoA Oxaloacetate \\ Aspartate” Citrate Fat acids, f \ sgrols l ‘ Purines Succinyl a-Ketoglutarate I / COA _— \ 0th er herrllgrfllllclrrlgslhyll Glutamate amino acids I Figure I7-Zn Biothemisrry, Sixth Edition @ 2on7w H Freeman and (nmpany [The Granger Collection] Unmmheredlinura w m Exam-fir], Sixth Edith": utmw H meanandcumpany Acetyl CoA Co A + H20 CIOO' _ Citrate H2 0%C/COO synthase I 'OOC—T—OH T’“ H, COO' C O o_ NADH + H+ Oxnlocmmie Cilruio Aconitase Malate deh dro enase NAD+ y 9 Too' COO‘ H— —OH HO—C—H 'OOC— —H CH T"’ I 2 COO' coo- _ "uh” lsocitrate lsoulrnlo Malate lyase synthase coo- coo- | CoA (I: TH; ”/ \0 CH; Acetyl CoA Glyoxylulo | +H20 C90- Sumnulo Figure17-23 Bin chemistry. Sixth Edition © 2007 W. H. Freeman and Company $00- 0 coo- “_c 0” ‘C/ synthase C00- 'OOC—i II I Cilruh | T"’ €le NADH + [1+ C00- C00' NAD“ Oxalouulul'o I s Willa!- lsocitrate Malate dehydrogenase NADH + H“ NAD+ dehydrogenase 'OOC + CO; fw \E¢° HO—C—H lH; Cl“; CIHZ Mulch I C00- C00- u-Kologllmlmh a—Ketoglutarate NAD“ Fumarase dehydrogenase + CoA complex CoA—S \c¢° NADH + w H20 "\c/COO' I + CO; H fH; C Succinate COO- Succinyl CoA / \ 1’0: I: dehydrogenase | synthetase THz "It"! I EH2 COO- FADHl CH2 GDP + p. ”MIMI“! FAD I GTP COO‘ + CoA Siminulo Figure17-15 Biochemistry, Six rh Edition © 1007 W.H.Freeman and Company ...
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