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Lecture_3 - Susan C Evans, PhD Lecture 3: Glycolysis...

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Lecture 3: Glycolysis Susan C Evans, PhD
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Glycolysis
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Glycolysis Glycolysis is the sequence of reactions that metabolizes 1 molecule of glucose to 2 molecules of pyruvate with the net production of 2 molecules of ATP Sequence of chemical (enzymatic) reactions that convert glucose (foodstuff) into pyruvate
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Anaerobic oxidation - Catabolism, which occurs in the absence of O 2 Aerobic oxidation – Catabolism, which occurs in the presence of O 2
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anaerobic anaerobic anaerobic aerobic
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History of glycolysis Buchner (1897) – Found by accident that yeast extracts could convert sucrose (a common kitchen preservative at the time) to ethanol Sucrose glucose + fructose (disaccharide) This experiment proved fermentation could occur outside living cells William Young (1905) - Discovered that the rate of fermentation decreased without the addition of phosphate (Pi). Therefore phosphate is required for the fermentation process two factors, which were required for fermentation. Zymase – heat labile nondialyzable fraction. Enzymes needed for glycolysis. Cozymase – heat stable, dialyzable fraction. Coenzymes needed for glycolysis (i.e. ATP, ADP, metal ions, NAD + ).
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History continued…. By 1940 all of the reactions of the glycolysis pathway were known from the research of Embden, Meyerhof, Parnas and Warburg Glycolysis is sometimes known as the Embden-Meyerhof pathway in the older textbooks.
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Review of sugar nomenclature Hexose - 6 carbon sugar Triose - 3 carbon sugar Aldose
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Lecture_3 - Susan C Evans, PhD Lecture 3: Glycolysis...

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