233_Chapter8.2-Protein_Structure_3(2)

233_Chapter8.2-Protein_Structure_3(2) - Chemistry 233...

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Unformatted text preview: Chemistry 233 Fundamentals of Biochemistry Protein Structure 3 Protein Structures: Where do they come from? X-ray crystallography Figure 8-35 X-Ray diffraction photograph of a single crystal of sperm whale myoglobin. diffraction pattern of a protein crystal Fourier transform analysis of the data gives the electron density. Figure 8-37 Sections through the electron density map of diketopiperazine calculated at the indicated resolution levels. Figure 8-36b Electron density maps of proteins. Electron density Resolution: Low High 2D NMR techniques for protein structure Figure 8-38a The 2D proton NMR structures of proteins. ( a ) A NOESY spectrum of a protein presented as a contour plot with two frequency axes 1 and 2 . Protein Stability What holds proteins together? electrostatic forces ion-ion interactions; close range forces Ex: -NH 3 +---- OOC- van der Waals forces between permanent and induced dipoles H-bonds Ex: -N-H ---- O=C- These are found in 2 o as well as 3 o structure...
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This note was uploaded on 03/12/2009 for the course CHEM 233 taught by Professor Daub during the Winter '09 term at Waterloo.

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233_Chapter8.2-Protein_Structure_3(2) - Chemistry 233...

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