233Chapter8.1_Protein_Structure_2(2)

233Chapter8.1_Protein_Structure_2(2) - Chemistry 233...

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Chemistry 233 Fundamentals of Biochemistry Protein Structure 2
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Another structural protein: Silk Fibroin Structure
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silk has regions of β -sheet structure with alternating Gly and Ala residues the alternating Gly and Ala side chains fit together and hold the β -sheets together
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Collagen Highly Repeating structure: Hyp and Hyl residues necessary for proper collagen structure proline and lysine residues are hydroxylated after protein synthesis, requiring ascorbic acid
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left-handed helix, 3.3 residues per turn, pitch = 2.86 nm . The triple helix of collagen.
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3 left-handed helices form a right-handed helix “tropocollagen” small Gly residues are small enough to fit inside the helix H-bonding with Gly amide N-H holds tropocollagen together e 8-30b X-Ray structure of the triple helical collagen
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many tropocollagen helices make a collagen fiber electron micrograph of collagen fiber
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