233Chapter_8.0_Protein_Structure(2)

233Chapter_8.0_Protein_Structure(2) - Chemistry 233...

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Unformatted text preview: Chemistry 233 Fundamentals of Biochemistry Protein Structure 1 Protein Structure: the shape of proteins Levels of structure: primary structure 1 o secondary structure 2 o tertiary structure 3 o quaternary structure 4 o Primary Structure Linear sequence of amino acids +H 3 N CH C CH 2 H N O C NH 2 O CH C H H N O CH C CH 2 H N O CH C CH 2 H N O CH 2 S CH 3 CH C CH 2 H N O CH 2 CH 2 CH 2 NH 3 + CH C CH 2 OH O SH sequence is not branched. can have disulfide bonds between Cys side chains Secondary Structure Consider the partial double bond character of the peptide bond: Restricted rotation means that the atoms of the peptide bond must be co-planar. the peptide bond can be in the cis or trans configuration: Figure 8-1 The trans-peptide group. Figure 8-2 The cis-peptide group. the plane of each peptide bond shares one C with the next peptide bond plane Figure 8-4 The torsional degrees of freedom in a peptide unit. rotation of the angles and changes the relative position of the amide planes some configurations are not possible steric hindrance which is BAD! Figure 8-6 Steric interference between adjacent residues. amachandran Plot (~1968): A plot of all of the ossible configurations of and ....
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This note was uploaded on 03/12/2009 for the course CHEM 233 taught by Professor Daub during the Winter '09 term at Waterloo.

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233Chapter_8.0_Protein_Structure(2) - Chemistry 233...

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