233hemoglobin_and_myoglobin_II

233hemoglobin_and_myoglobin_II - Chemistry 233 Fundamentals...

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Unformatted text preview: Chemistry 233 Fundamentals of Biochemistry Hemoglobin and Myoglobin II Figure 10-6 Effect of pH on the O 2-dissociation curve of Hb: the Bohr effect. The Bohr Effect his was observed by Christian Bohr nd reported in 1904. ncreasing acidity hifts the Hb binding urve to the right (away from the Y-axis ) What physiological conditions affect the pH of the blood? M etabolism generates CO 2 and lactic acid CO 2 + H 2 O HCO 3- + H + lactic acid lactate HO CH C CH 3 OH O HO CH C CH 3 O- O H+ + What is the effect of the increasing acidity on Hb: Hb H + + O 2 Hb O 2 + H + As metabolism increases, the pH goes down and more O 2 is released . Hb binds either protons or O 2 . Where do the Bohr protons bind? In the T-state of Hb, C-terminal changes when O 2 binds: HN CH C O- O +HN N H NH CH C NH O C O- O HN CH C-O O N HN NH CH C NH O C O- O O 2 binding H+ T-state: Bohr proton R-state: Hb can also bind CO 2 at the N-termini: Carbamate formation increases the acidity of the blood and more O 2 released due to the Bohr Effect O C O protein H 3 N+ C NH protein O O- + H+ + Summary of the Bohr Effect:...
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This note was uploaded on 03/12/2009 for the course CHEM 233 taught by Professor Daub during the Winter '09 term at Waterloo.

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233hemoglobin_and_myoglobin_II - Chemistry 233 Fundamentals...

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