Unformatted text preview: Cooperativity, according to Christine (Christine Hand, Summer 2005) This was written by Christine to some CHEM 233 students in the summer of 2005 . It is a great way to explain cooperativity in a way that everyone who has ever been in high school can understand. So the Hill coefficient represents to cooperativity of the different subunits of Hb. It is >1 for Hb indicating that the binding of one oxygen molecule causes the protein to have a higher affinity for the binding of subsequent O 2 molecules. The basis of this cooperativity is the T --> R state conformational shift. Because of the structure of Hb, the binding of O 2 results in a series of movements that must occur together, these movements influence the other subunits and causes them to have a similar movement which increases the probability of binding. The cooperativity, which is measured by the Hill coefficient, is a property of the protein as a whole; it does not increase or decrease with the conversion of the protein from R or T state, so...
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