Christine_on_Cooperativity

Christine_on_Cooperativity - Cooperativity according to...

Info icon This preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
Cooperativity, according to Christine (Christine Hand, Summer 2005) This was written by Christine to some CHEM 233 students in the summer of 2005 . It is a great way to explain cooperativity in a way that everyone who has ever been in high school can understand. So the Hill coefficient represents to cooperativity of the different subunits of Hb. It is >1 for Hb indicating that the binding of one oxygen molecule causes the protein to have a higher affinity for the binding of subsequent O 2 molecules. The basis of this cooperativity is the T --> R state conformational shift. Because of the structure of Hb, the binding of O 2 results in a series of movements that must occur together, these movements influence the other subunits and causes them to have a similar movement which increases the probability of binding. The cooperativity, which is measured by the Hill coefficient, is a property of the protein as a whole; it does not increase or decrease with the conversion of the protein from R or T state, so the number is the same regardless of the state of the protein.
Image of page 1
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern