Cumsky 6 - Bio 99B Dr Cumsky Lecture 6 Response Elements...

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Bio 99B – Dr. Cumsky Lecture # 6
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Response Elements REs are binding sites for a particular type of Txn factor These Txn factors respond to physiological signals and regulate Txn The steroid hormone superfamily of Txn factors is an example
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Table 29-4, p. 966
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Fig. 29-26, p. 966
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What are Transcription Factors? Proteins, other than RNAP, that are involved in Txn Can act positively or negatively You have already learned about several Txn factors; can you name them? Lac repressor CRP Trp repressor
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Transcription Factor Properties Transcription factors can have one or more of the following properties: Bind DNA (Major groove, generally) Bind ligands (small molecules, cofactors) Bind to/interact with other proteins Bind to/interact with RNAP Transcription factors tend to be modular in structure
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TBP
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Transcription Factor Properties Transcription factors can have one or more of the following properties: Bind DNA (Major groove, generally) Bind Ligands (small molecules, cofactors) Bind other proteins Bind or interact with RNAP
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