lecture_notes_10_29_07 - Other 6 classes have 2 alleles...

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Genetic Recombination and Linkage, outline – Lecture 9 2007 Genetic Recombination and Linkage II [Reading: SS 129-142; CR 277-281] Crossing over and genetic distance 2 point test determines map distance between 2 genes (‘points’) Gene 1 Region 1-2 Gene 2 4 progeny classes: 2 NCO (= nonrecombinant = parental alleles) + 2 CO Units of map distance = centiMorgans Map distance = %CO = 100 CO / (CO + NCO) 3 point test determines gene order, map distance, coefficient of coincidence , and interference Gene 1 Region 1-2 Gene 2 Region 2-3 Gene 3 8 progeny classes; 2 NCO most plentiful, have all 3 alleles from 1 parent
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Unformatted text preview: Other 6 classes have 2 alleles from one parent, 1 from the other 2 DCO (double crossovers) are the least plentiful two classes Gene order : The allele from one parent is in the middle, other two flank it Remaining 4 classes are SCO (single crossovers): 2 for one region (SCO-Region 1-2), 2 for other (SCO-Region 2-3) Map distance Region 1-2 = % SCO-Region 1-2 + % DCO Map distance Region 2-3 = % SCO-Region 2-3 + % DCO Coefficient of coincidence: c = observed freq. DCO / expected freq. DCO Exp. Freq. DCO = (% CO-Region 1-2) x (% CO-Region 2-3) Interference: I = 1 - c...
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