DollyGroupC-Revised - made from a ewe that isn’t...

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Click to edit Master subtitle style 10/5/09 We’re Not Convinced. Clint Fuller, Carolyn Johnson, Chau Nguyen, Matthew Saponaro Other evidence that we'd like to see before concluding that nuclei from adult cells can support normal development of clones.
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10/5/09 Other Things We’d Like to Know Why such a high loss of fetuses? 13 recipients and one pregnancy from the mammary gland Of 6 live births, only one survived – Dolly Autopsies were “inconclusive” – only 2 deaths explained. Follow up studies about what the reprogramming factors are.
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10/5/09 Need for Control Groups Can’t tell if survivability rates are normal Low percentage of fetal survivability What are the norms for other invitro pregnancies of lambs?
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10/5/09 Dolly’s Origin What kind of cells did Dolly actually originate from? Sample was 90% mammary gland cells Possibility of fetal cells or adult stem cells in the sample. Another experiment of a clone made from a ewe that isn’t
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Unformatted text preview: made from a ewe that isn’t 10/5/09 Morphological issues Need more data for each species (Ex: not giving Scottish Black Face birth weight) Need more control data for each species – how similar are lambs in pregnancy time, birth weight etc. (The data seems quite similar for 10/5/09 Microsatellite problems. • Are four microsatellite regions enough to tell the organisms are the same? Does that species have enough polymorphisms at those locations to conclude the organisms are the same? • Having a control would be more conclusive (showing the 10/5/09 Follow-Up Questions on the Monitor Dolly’s survivability – is she an anomaly? ◦ We would like to see if she has a normal development rate (in comparison to her breed) ◦ Additionally, a control of a lamb bred in-vitro would show that any problems aren’t necessarily associated with in-vitro fertilization....
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