Circadian oscillation of nucleotide excision repair in mammalian

Circadian oscillation of nucleotide excision repair in mammalian

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Click to edit Master subtitle style 10/5/09 Circadian oscillation of nucleotide excision repair in Chau, Carolyn, Clint, Sina
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10/5/09 Questions – evidence requested What evidence in the article shows that DNA repair is at the lowest level of activity (in the morning)? Why is it more effective for chemotherapy to be performed in the early morning? How do we know the enzyme is linked to DNA repair?
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10/5/09 Claims Newspaper Article: Chemotherapy is most effective early in the morning when the enzyme linked to DNA repair is at its lowest level of activity. Research Article: The circadian oscillation of the repair capacity is caused at least in part by the circadian oscillation of the xeroderma pigmentosum A DNA damage recognition
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Unformatted text preview: protein. 10/5/09 Definitions: Circadian rhythm or clock Xeroderma pigmentosum Excision repair 10/5/09 The effect of circadian time on excision repair activity in mouse cerebrum ZT0 is time of light on a 12h light:12h dark lighting regimen 10/5/09 The effect of circadian time on excision repair activity in mouse cerebrum 10/5/09 10/5/09 Effect of the circadian clock on excision protein levels Per2 and Cry 1 are antiphase with Bmal1 10/5/09 There is a link between the oscillation and the repair DNA but this study did not cover the added variable of chemotherapy Only hypothesized about it. The evidence provided justifies the claim in the research article....
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Circadian oscillation of nucleotide excision repair in mammalian

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