circadian group edit

circadian group edit - Analysis of Follow-Up Experiments...

Info iconThis preview shows pages 1–7. Sign up to view the full content.

View Full Document Right Arrow Icon
Click to edit Master subtitle style 10/5/09 Analysis of Follow-Up Experiments Chau, Carolyn, Sina, Clint
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
10/5/09 A Certain Protein Oscillates Opposite XPA In a normal subject, there are proteins that are present in circadian oscillation, an oscillation opposite that of XPA protein, that protect DNA and DNA repair mechanisms from the deleterious effects of the natural environment. If a protein has been isolated that is thought to protect DNA and DNA
Background image of page 2
10/5/09 Data Supporting Claim For data that supports this claim we would expect to see low levels of DNA damage and XPA damage at times where the oscillation of the protein in question is in its zenith. The oscillation of XPA would protect the DNA by repair at its zenith. We would also see large amounts of damage over night when XPA is in its nadir if no protein was present. 0 10 20 30 40 50 60 70 80 90 100 12:00 AM 6:00 AM 12:00 PM 9:00 PM XPA Concentration Concentration of protein in question
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
10/5/09 Contradictory Evidence For data that refutes the claim we would see normal levels of DNA damage during the day and elevated damage at night and in the early morning when XPA is at its lowest.
Background image of page 4
10/5/09 Validity of Claim 1 The claim that XPA concentration is possibly inversely correlated to the concentration of a DNA protection proteins is valid. Yet the negating evidence needed is provided by the original article: There is solid evidence showing that excision levels are highest during the day and elevated at night and thus no additional experimentation is need to justify.
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
10/5/09 Heat instead of Light as Circadian Stimulus Other external cues can give rise to
Background image of page 6
Image of page 7
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 03/15/2009 for the course CHEM 262L taught by Professor Mbadugua during the Spring '08 term at UNC.

Page1 / 19

circadian group edit - Analysis of Follow-Up Experiments...

This preview shows document pages 1 - 7. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online