circadian group edit - Analysis of Follow-Up Experiments...

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Click to edit Master subtitle style 10/5/09 Analysis of Follow-Up Experiments Chau, Carolyn, Sina, Clint
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10/5/09 A Certain Protein Oscillates Opposite XPA In a normal subject, there are proteins that are present in circadian oscillation, an oscillation opposite that of XPA protein, that protect DNA and DNA repair mechanisms from the deleterious effects of the natural environment. If a protein has been isolated that is thought to protect DNA and DNA repair proteins, then adjusting the
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10/5/09 Data Supporting Claim For data that supports this claim we would expect to see low levels of DNA damage and XPA damage at times where the oscillation of the protein in question is in its zenith. The oscillation of XPA would protect the DNA by repair at its zenith. We would also see large amounts of damage over night when XPA is in its nadir if no protein was present. 0 10 20 30 40 50 60 70 80 90 100 12:00 AM 6:00 AM 12:00 PM 9:00 PM XPA Concentration Concentration of protein in question
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10/5/09 Contradictory Evidence For data that refutes the claim we would see normal levels of DNA damage during the day and elevated damage at night and in the early morning when XPA is at its lowest.
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10/5/09 Validity of Claim 1 The claim that XPA concentration is possibly inversely correlated to the concentration of a DNA protection proteins is valid. Yet the negating evidence needed is provided by the original article: There is solid evidence showing that excision levels are highest during the day and elevated at night and thus no additional experimentation is need to justify.
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10/5/09 Heat instead of Light as
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  • Spring '08
  • Mbadugua
  • DNA, DNA repair, DNA Damage, contradictory evidence

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