Lecture 07 - Lecture 7: Phage Genetics Bacteriophage what...

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Lecture 7: Phage Genetics Bacteriophage – what are they? Phage Recombination – how is this done? Transduction- specialized and generalized
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Bacteriophage – from the Greek “to eat bacteria” Phage are host specific and designations refer to the host – Coliphage infect E. coli Staphylophage infect Staphlococcus , etc…
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Infection: A) Absorption A) Irreversible attachment A) Sheath Contraction A) Nucleic Acid Injection A) Translating the genome A) Replication A) Assembly A) Burst
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Phage Therapy – use Bacteriophage to battle bacterial infections. Initially investigated by George Eliava, formally of the Pasteur Institute, later of the Eliava Institute in Tbilisi Georgia . The west dropped phage therapy once broad range antibiotics were discovered. George Eliava - executed in 1937 for poisoning water wells with pathogenic bacteria. Perhaps also because he was romantically linked to a women that was pursued by Lavrenti Beria. Lavrenti Beria – Chief of Security and Police during Stalin’s Great Purge.
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Phage Therapy – Advantages 1) Species specific – only effect pathogenic bacteria 2) Very fast acting 3) Phage evolve with bacteria – avoiding problems of resistance 4) Faster development – already exist in nature. Disadvantages 1) Species specific – need to know identity of infectious bacteria 2) Patient my mount immune response 3) Delivery may be difficult Currently ~90,000 people/year die of infections. Development and approvals of new antibacterial agents have decreased by 56 percent over the past 20 years, the last new antibiotic was synthesized in 1992.
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Lecture 07 - Lecture 7: Phage Genetics Bacteriophage what...

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