Lecture 18 - Mutation Changes in DNA: Point Mutations...

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Changes in DNA: 1) Point Mutations 1) Insertions 1) Deletions 1) Inversions 1) Translocations Mutation
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Point Mutations DNA: 1) Transitions - a purine is changed to a different purine or a pyrimidine is changed to a different pyrimidine. AT GC or TA CG 1) Transversions - a purine is changed to a pyrimidine or a pyrimidine is changed to a purine. AT TA or GC TA or AT CG or GC CG
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Point Mutations Proteins*: 1) Silent Mutations - changes codon without changing amino acid 1) Neutral Mutations – changes to an amino acid that doesn’t alter protein function 1) Missense Mutation – changes to amino acid that alters protein function 1) Nonsense Mutation – changes codon to a stop, truncating protein UUU UU C PHE PHE UCU A CU SER THR CCC C G C PRO ARG CAG U AG GLN Stop Amber Mutation
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Point Mutations Can Also Effect Gene Activity through: 1) Promoter up 1) Promoter down 1) Loss of splicing 1) Gain of cryptic splice site 1) ????
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Insertions and Deletions Protein: Frame shift: changes the reading frame to generate altered protein Multiples of three: inserts or deletes amino acids in frame ATG GCT ACG CGT AGT TTA CCT TGA ATG GCT T AC GCG TAG M A T R S L P * M A Y A * ATG GCT ACG CGT AGT TTA CCT TGA ATG GCT TTT ACG CGT AGT TTA CCT TGA M A T R S L P * M A P T R S L P *
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Point Mutations Effect Splicing
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Lecture 18 - Mutation Changes in DNA: Point Mutations...

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