F08Lecture9

F08Lecture9 - heme site Fig. 5-17 Lehn Fig. 3-13 B and T...

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Fig. 5-12 Lehn
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Fig. 5-10 Lehn
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Fig. 5-10 Lehn
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Fig. 5-10 Lehn
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Fig. 5-11 Lehn
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– Classic Example of an Allosteric Protein Hb has both low and high affinity binding states Hb undergoes a transition from the low affinity T state to high affinity R state as more oxygen binds Oxygen binding in one subunit leads to quaternary structure changes in tetram -- triggers T to R transition in other subunits Oxygen binding stabilizes R state Key amino acids surrounding heme ring change position during the transition - local movement propogated to other subunits which creates higher affinity binding sites in other subunits. siologic Relevance!
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Fig. 5-16 Lehn
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Fig. 5-9 Lehn
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Fig. 5-18a Lehn
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Allosteric Modulation: BPG 2,3-bis-phosphoglycerate (BPG) binds Hb and decreases the binding affinity for oxygen BPG’s negative groups form hydrogen bonds and salt bridges in the central subunit interface of Hb and stabilize deoxy (‘T’) Binding site distinct from heme site — allosteric But influences affinity of
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Unformatted text preview: heme site Fig. 5-17 Lehn Fig. 3-13 B and T Fig. 3-14 B and T HbS: 2 2 E6V Fig. 5-20 Lehn Fig. 5-20 Lehn Sickle Cell (HbS) Fiber RBC adopts sickle shape Polymerization only occurs in the deoxy (T) form sickling occurs in capillaries Sickle cells do not deform easily in transport through capillaries and rupture easily microvascular vasoocclusion and hemolytic anemia HbS increased resistance against malaria Box 5-1 Lehn Box 5-1 Lehn Protein Interactions Modulated by Chemical Energy Actin, Myosin, and Molecular Motors Fig. 5-29 Lehn Fig. 5-29 Lehn Fig. 5-30 Lehn Fig. 5-27 Lehn Fig. 5-27 Lehn Fig. 5-27 Lehn Fig. 5-28 Lehn Fig. 5-28 Lehn Fig. 5-30 Lehn Fig. 5-28 Lehn Fig. 5-28 Lehn Fig. 14-15 B and T Fig. 5-28 Lehn Fig. 5-31 Lehn Fig. 14-15 B and T Fig. 5-31 Lehn Fig. 5-31 Lehn Fig. 5-31 Lehn Fig. 5-31 Lehn Fig. 14-16 B and T movie ENZYMES Fig. 6-2 Lehn Fig. 6-3 Lehn...
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This note was uploaded on 03/15/2009 for the course BIBC BIBC 100 taught by Professor Buehler during the Fall '09 term at UCSD.

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F08Lecture9 - heme site Fig. 5-17 Lehn Fig. 3-13 B and T...

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