practicefinalF08

practicefinalF08 - PRACTICE FINAL for FALL 2008 1. When...

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PRACTICE FINAL for FALL 2008 1. When protein X is being cleaved by trypsin: A. the tetrahedral transition state involves a covalent bond between the substrate and Serine B. the transition state is stabilized in the oxyanion hole C. Oxygen from water forms hydrogen bonds with residues in the oxyanion hole D. All of the above are true E. Only A and B are true 2. Under what conditions would you have glycogen synthesis? A. PKB is active/ GSK3 is active/ GS active B. PKB is active/ GSK3 is inactive/ GS inactive C. PKB is inactive/ GSK3 is active/ GS is active D. PKB is active/ GSK3 is inactive/ GS is active E. PKB is active/ GSK3 is active/ GS is inactive 3. Which of the following statements about the Na+/K+ ATPase pump is FALSE? A. It is an integral membrane protein. B. It pumps 3 Na+ ions into the cell and 2 K+ ions out of the cell. C. It requires ATP D. It is inhibited by oubain E. None of the above. 4. Which of the following protein(s) is not a transmembrane protein: A. class I MHC B. T-cell receptor C. IRS-1 D. Nicotinic Acetylcholine Receptor E. A, B and C are not transmembrane proteins F. Both A and B are not transmembrane proteins G. All of the above proteins are transmembrane 5. Which of the following factors will influence the native conformation of a protein? A. pH of the solution B. Concentration of salt in solution C. Sequence of the protein D. All of the above E. A and C only 6. Cytosolic Ca(2+) exists at low concentrations ~ <10 -7 M within cells because of the following: A. Ca(2+)/ Na(2+) antiporter B. Ca(2+) binding proteins C. Ca(2+) pumped into organelles D. IP3 E. A, B and D are correct, but C is incorrect F. A, B and C are correct, but D is incorrect G. A and D are incorrect, but B and C are correct 1
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7. If you had a mutation in the insulin receptor that abolished its affinity for ligand, what would be the effect on Ras? A. It would always be active B. It would never be active C. It would be active when insulin was present D. It would be active when insulin was not present 8. What small molecule must Ras bind in order to be active? A. ATP B. GTP C. cAMP D. Raf1 9. Some mutations in Ras cause constituitive activation, thus promoting the transition to oncogenicity (causing cancer). Which of the following mutations would have the opposite effect and block the transformation to oncogenicity? A. mutation of MEK that made MEK unable to bind ATP B. mutation in Grb2 that made it unable to bind Sos C. a mutation in Irs-1 that made it unable to bind MEK D. all of above E. none of above 10. Ouabain causes A. Increased heart contraction by blocking Na+/K+ ATPase B. Decrease heart contraction by blocking Cl- channels C. Decrease heart contraction by blocking Na+, K+ ATPase D. Increase heart contraction by activation of Na+ channels E. Decrease heart contraction by activation of Na+ channels 11. What is the specificity of AchR? A.
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This note was uploaded on 03/15/2009 for the course BIBC BIBC 100 taught by Professor Buehler during the Fall '09 term at UCSD.

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practicefinalF08 - PRACTICE FINAL for FALL 2008 1. When...

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