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practicefinalF08 - PRACTICE FINAL for FALL 2008 1 When...

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PRACTICE FINAL for FALL 2008 1. When protein X is being cleaved by trypsin: A. the tetrahedral transition state involves a covalent bond between the substrate and Serine B. the transition state is stabilized in the oxyanion hole C. Oxygen from water forms hydrogen bonds with residues in the oxyanion hole D. All of the above are true E. Only A and B are true 2. Under what conditions would you have glycogen synthesis? 3. Which of the following statements about the Na+/K+ ATPase pump is FALSE? 4. Which of the following protein(s) is not a transmembrane protein: 5. Which of the following factors will influence the native conformation of a protein? A. pH of the solution B. Concentration of salt in solution C. Sequence of the protein D. All of the above E. A and C only 6. Cytosolic Ca(2+) exists at low concentrations ~ <10 -7 M within cells because of the following: 1
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7. If you had a mutation in the insulin receptor that abolished its affinity for ligand, what would be the effect on Ras? 8. What small molecule must Ras bind in order to be active? 9. Some mutations in Ras cause constituitive activation, thus promoting the transition to oncogenicity (causing cancer). Which of the following mutations would have the opposite effect and block the transformation to oncogenicity? A. mutation of MEK that made MEK unable to bind ATP B. mutation in Grb2 that made it unable to bind Sos C. a mutation in Irs-1 that made it unable to bind MEK D. all of above E. none of above
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