Lecture2 - Protein Metabolism • Structure& Function...

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Unformatted text preview: Protein Metabolism • Structure & Function • Amino Acid Pool • N 2 Balance • Exercise (protein synthesis v degradation) • Glucose-Alanine Cycle • Gluconeogenesis • Training Adaptations Occurs primarily in the liver Nitrogen Balance N 2 Input = N 2 Output (diet) (excreted) Balance (gm N 2 /day) Most healthy adults with adequate diet will be in N 2 balance Positive N 2 balance N 2 Input > N 2 Output Positive N 2 balance • Growing children • Intense weight training + anabolic steroids + high protein diet * Incorporation of AA’s into synthesis of body proteins Negative N 2 balance N 2 Input < N 2 Output Negative N 2 balance Sick, starving/fasting, aging * Loss of body proteins including muscle Acute Exercise Protein Synthesis during exercise • The degree of depression in protein synthesis is ∝ to both the intensity and duration of exercise • Biosynthetic pathways, such as protein synthesis, which require input of ATP are generally inhibited during exercise - thus, energy charge regulation...
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This note was uploaded on 03/18/2009 for the course IPHY 4650 taught by Professor Robertmazzeo during the Spring '09 term at Colorado.

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Lecture2 - Protein Metabolism • Structure& Function...

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