L15 chapter 14

L15 chapter 14 - Genetics Biology 2306.04 Ch 14: RNA...

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Unformatted text preview: Genetics Biology 2306.04 Ch 14: RNA Molecules and RNA Processing Not true in eukaryotes Coding sequences (exons) in a gene may be interrupted by noncoding sequences (introns) Introns rare in bacteria; common in eukaryotes mRNA Structure pre-mRNA Processing Eukaryotes (occurs in nucleus) addition of 5 cap addition of 3 poly(A) tail removal of introns Addition of 5 Cap Modified nucleotide usually 7-methyl guanosine 5-5 bond methylation of additional nucleotides addition of 5 cap Function of 5 Cap binding of ribosome to mRNA for translation stabilizes mRNA affects intron removal Addition of the Poly(A) Tail Poly(A) tail 50-250 A nucleotides at 3 end of mRNA Two steps cleavage of 3 end polyadenylation addition of 3 poly(A) tail Function of poly(A) tail Increases stability of mRNA Required for ribosome binding to 5 cap Intron Removal (splicing) Occurs in the spliceosome snRNAs (U1, U2, U4, U5, U6) + proteins snRNPs = 1 snRNA + proteins Requires consensus sequences pre-mRNA Alternative RNA Processing...
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This note was uploaded on 04/29/2008 for the course BIO 2306 taught by Professor Durhkopf during the Spring '08 term at Baylor.

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L15 chapter 14 - Genetics Biology 2306.04 Ch 14: RNA...

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