L18 chapter 17

L18 chapter 17 - Genetics Bio 2306.04 Ch 17 Control of Gene...

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Unformatted text preview: Genetics Bio 2306.04 Ch 17: Control of Gene Expression in Eukaryotes Gene Regulation in Eukaryotes • Many similarities to regulation in prokaryotes • Some differences – no operons – presence of chromatin – more positive control – regulation at multiple levels Changes in DNA Structure Chromatin Structure • Chromatin structure inhibits transcription • DNase I hypersensitivity – no digestion if DNA is tightly bound to histones • Acetylation of histones – addition of CH 3 CO groups – neutralizes + charge, disrupts chromatin – allows access of proteins/polymerases to DNA acetylation no acetylation deacetylase enzymes no acetylation acetylation acetyltransferase enzymes (allows transcription) (restores chromatin repression) Methylation of DNA • addition of CH 3 groups • associated with repression of transcription • methyl groups added to cytosine – 5-methylcytosine • commonly added to C bases next to G – CpG islands common near transcription start sites G C C G •...
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L18 chapter 17 - Genetics Bio 2306.04 Ch 17 Control of Gene...

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