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L11 ch 10 gene - Genetics Bio 2306.04 Genetics Chapter 10...

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Genetics Bio 2306.04, Genetics Chapter 10: Chemical Nature of the Gene
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Characteristics of Genetic Material Genetic material must contain complex information. Genetic material must replicate faithfully. Genetic material must encode phenotype. WHAT IS LIFE? by Erwin Shrödinger "aperiodic crystals"
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History of DNA Structure Miescher: (1868) Observed nucleus of WBC and found material was slightly acidic with high phosphorus (nucleic acid) Kossel - discovered bases (late 1800s) Levene - nucleotide structure consisted of sugar, phosphate, base (by 1930) tetranucleotide theory : DNA contained 4-nucleotide units, each containing all 4 nucleotides Chargaff’s rules: disproved tetranucleotide theory A = T; G = C
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The Transforming Principle Griffith (1928) Streptococcus pneumoniae causes pneumonia Strains I, II, III, IV S - smooth colony (virulent) R - rough colony (nonvirulent)
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Hershey and Chase Experiment Demonstrated that DNA (not protein) was transmitted during viral reproduction
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