15.FA08 - NADH ATP, ADP Ca +2 key allosteric enzymes: the...

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Metabolic Biochemistry BIBC102 Lecture 15 October 29, 2008
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Pyruvate dehydrogenase as seen by electronmicroscopy E. coli enzyme: Mass > 4.5x10 + 2 complex
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Fig. 16.6
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Stereospecificity of the aconitase reaction with citrate
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LNC 16.14
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For the moment consider only NAD + as a substrate in this reaction
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Carbons derived from acetyl-CoA
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? The a-ketoglutarate dehydrogenase complex is very similar to the pyruvate dehydrogenase complex mistake in the slides provided
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Note: carboxyls in trans
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LNC Fig.16.15 the Krebs cycle is amphibolic
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LNC Fig.16.18 regulatory molecules:
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Unformatted text preview: NADH ATP, ADP Ca +2 key allosteric enzymes: the dehydrogenases citrate synthase THE GLYOXYLATE CYCLE LNC Chapter 16, pages 623-626 LNC Fig.16.7 the only membrane-bound enzyme in the TCA cycle The bypass eliminates two decarboxylation reactions LNC Fig.16-20 C 6 C 6 C 4 C 4 C 4 C 2 C 2 C 2 from oxidation of fatty acids LNC Fig.16.22 cellulose LNC Fig.16.23 isocitrate dehydrogenase: inactivated by phosphorylation isocitrate lyase: inactivated by low ATP (high AMP/ADP) End of Lecture 15 October 29, 2008...
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This note was uploaded on 03/21/2009 for the course BIBC 100 taught by Professor Nehring during the Fall '07 term at UCSD.

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15.FA08 - NADH ATP, ADP Ca +2 key allosteric enzymes: the...

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