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20.FA08 - Metabolic Biochemistry BIBC102 Lecture 20 Total...

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Metabolic Biochemistry BIBC102 Lecture 20 November 10, 2008
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Total quantity of ATP produced per glucose oxidized to CO 2 (under aerobic conditions) Assignment for the Sections next week To be discussed in a future lecture
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for NADH: P/O ratio ~ 2.5 for succinate: P/O ratio ~ 1.5 Assignment for the Sections next week
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Thermoregulation Thermogenesis
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(limited amount) In the presence of an uncoupler the P/O ratio is reduced to zero
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LNC 19-17b Oligomycin is a highly specific inhibitor of the ATP synthase DNP is an uncoupler
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Two commonly used uncouplers in mitochondrial research: DNP FCCP They can shuttle protons across lipid bilayers
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Uncoupling protein, UCP, (physiological) DNP, FCCP (pharmacological)
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LNC 19-28 We have > 6 genes for different isozymes of uncoupling proteins”: UCP-1, UCP-2, UCP-3, ….. they are differentially expressed in different tissues and cells
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Hibernating animals produce heat in their brown adipose (fat) tissue by having large amounts of UCP-1 in their mitochondria
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Mills, et al., NATURE | VOL 426 | 27 NOVEMBER 2003 | T
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