21.FA08 - Metabolic Biochemistry BIBC102 Lecture 21...

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Metabolic Biochemistry BIBC102 Lecture 21 November 12, 2008
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S UBSTRATE LEVEL PHOSPHORYLATION GAP + P i + NAD + NADH + 1,3-bisphosphoglycerate 1,3-bisphosphoglycerate + ADP ATP + 3-phosphoglycerate 1 ATP produced per NAD+ reduced per GAP used up per 3-PG produced There is a precise stoichiometry
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OXIDATIVE PHOSPHORYLATION NADH + 1/2 O 2 + H + NAD + + H 2 O ~ 3 ADP + ~ 3 Pi ~ 3ATP <3 ATP produced per NADH oxidized per H 2 O produced per 1/2 O 2 consumed ( P/O ratio ~ 2.5 ) There is no precise stoichiometry, because protons can find other paths to return to the matrix
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Regulation of OXPHOS:
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Mitochondria contain DNA (~16.5 kb) mtDNA encodes 2 rRNAs 22 tRNAs 13 proteins (in animals) mtDNA can have mutations causing mitochondrial diseases
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GLUCONEOGENESIS LNC Chapter 14, Section 14.4 PENTOSE PHOSPHATE SHUNT LNC Chapter 14, Section 14.5
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LNC Fig. 14-15 salvaging lactate after glycolysis metabolism of amino acids from protein metabolism of lipids and fat* PHOTOSYNTHESIS
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In plants/seedlings: from glyoxysome In animals: oxaloacetate is a key intermediate
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21.FA08 - Metabolic Biochemistry BIBC102 Lecture 21...

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