MH5 - Minh Le m8le@ucsd.edu; BIPN100 OH: Mon. 11-11:50a;...

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Minh Le m8le@ucsd.edu ; BIPN100 OH: Mon. 11-11:50a; Handout 5 Endocrine System Hormones- global target with slow action A. Types of Hormones Released Type Fxn/ Example Endocrine Release hormone into I.F./ Tissue Paracrine Target nearby cells Eicosanoid Autocrine Target Itself Neurocrine Released by Neurons Exocrine Secretion into duct, exiting body. Sweat Gland, Tears B. Types of Hormones Type Subtype Secreted By Example Amines Catecholamines A.D.; Sym NS Epin, NE, Dop Thyroid Hormones Thyroid Gland T3 and T4 Peptides/ Protein None Pituitary, Pancreas Ant. Pit; Insulin/Glucagon Eicosanoids Prostaglandins Local Secretion Arachidonic Acid Hydrophobic vs. Hydrophilic Hormones: - Hydrophilic Hormones binds to membrane bound receptors a. Examples) Hypothalamic Hormones, pituitary hormones, glucagons, insulin, parathyroid hormone, Epin, NE, and Dopamine. -Adrenal Medulla release Epin and NE during Sympathetic activation. -Hydrophobic Hormones binds either to receptors in cytosol and/or nucleus. a. Binding of hormone in cytosol translocation into nucleus increase in gene expression increase in protein synthesis. Or it can bind directly to the nucleus and same mechanism occurs. b. Examples are Steroid and Thyroid Hormones derivatives of cholesterol - Adrenal Cortex secretes 2 major types of steroid hormones 1) Mineralcorticoids: Aldosterone reabsorbs Na+ from binding and secretes K+ 2) Glucocorticoids: Cortisol related in metabolism, ant-inflammatory responses, stress related. 3) Sex Steroids: Testosterone, Estradiol testosterone is converted to estradiol by aromatase. Type of Receptors for the Hydrophilic Hormones: Alpha 1 Alpha 2 Beta1, 2, 3
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Diagram of Gs: Diagram of Gq: - Calcium is also a 2 nd intracellular messenger can 1. trigger exocytosis and 2. muscle contractions, 3. and it can also bind to a sensor protein called calmodulin.
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This note was uploaded on 03/21/2009 for the course BIPN 100 taught by Professor French during the Spring '07 term at UCSD.

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MH5 - Minh Le m8le@ucsd.edu; BIPN100 OH: Mon. 11-11:50a;...

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