Chapter 22-2

Chapter 22-2 - 1 CHEM 262 Wei You Chapter 22. Reaction of...

Info iconThis preview shows pages 1–5. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: 1 CHEM 262 Wei You Chapter 22. Reaction of Benzene and its Derivatives (2) 04/16/2008 Wed Chapter 23 (1) 04/21/2008 Mon Chapter 23 (2) 04/23/2008 Wed Review session 04/25/2008 Fri Practice problems (5) 04/28/2008 Mon Answer key uploaded 04/30/2008 Wed Office hour 4pm to 6pm Final: May 2, 2008 4pm to 6pm Di- and Polysubstitution Orientation: substituents are classified as either ortho-para directing (direct incoming groups preferentially to ortho & para positions) or meta directing (direct to meta position) toward further substitution Rate substituents are classified as activating (cause the rate of a second substitution to be greater than that for benzene) or deactivating (cause rate to be lower) toward further substitution 3 Di- and Polysubstitution -OCH 3 is ortho-para directing -NO 2 is meta directing OCH 3 HNO 3 CH 3 COOH OCH 3 NO 2 OCH 3 NO 2 H 2 O p-Nitroanisole (55%) o-Nitroanisole (44%) Anisole + + + COOH HNO 3 H 2 SO 4 NO 2 COOH COOH NO 2 NO 2 COOH 100C m- Nitro- benzoic acid (80%) Benzoic acid + + + o- Nitro- benzoic acid (18%) p- Nitro- benzoic acid (2%) 4 Di- and Polysubstitution...
View Full Document

Page1 / 19

Chapter 22-2 - 1 CHEM 262 Wei You Chapter 22. Reaction of...

This preview shows document pages 1 - 5. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online