Exam II - Biochem Connections Notes

Exam II - Biochem Connections Notes - Exam II BioChem...

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Exam II – BioChem Connections Enzymes as Markers for Disease Lactate dehydrogenase (LDH) -found in specific tissues – the heart and skeletal muscles easy to separate chromatographically -can exist in 5 different forms – isozymes -elevated levels of any form of LDH indicates tissue tammage -heart LDH – heart attacke Creatine kinase (CK) -occurs in heart, brain, and muscles -from brain – stroke -from heart – heart attack shows up faster than LDH Acetylcholinesterase (ACE) -conrolls certain nerve impulses -farm pesticides interfere with it’s productions -farmers are tested regularlty More than 20 enzymes are tested clinically -active in pancreas, RBC’s, liver, heart, brain, prostate gland, and other endrocine organs Practical Information form Kinetic Data: Four aspects of Kinetic Data are useful to compare: M K , cat k (turnover number), cat k / M K ratios, and specific locations of enzymes Comparison of M K Hexokinase: M K = 0.15 nM for glucose Glucokinase: ( an isozyme of hexokinase, present in liver)
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This note was uploaded on 03/22/2009 for the course CHEM 430 taught by Professor Redinbo during the Spring '07 term at UNC.

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Exam II - Biochem Connections Notes - Exam II BioChem...

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