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Unformatted text preview: erent brain structures Priming (neocortex) Eyeblink condi<oning in rabbit Human amnesia ‐ habit learning to compensate 7 2/25/09 Other causes of amnesia (explicit memory deﬁcit) • 1) ischemia: loss of blood/oxygen to brain – Pa<ent R.B. = very selec<ve hpc damage (CA1) & s<ll amnesic (but less than H.M.) – Hpc damage suﬃcient for amnesia but other areas contribute • 2) Korsakoﬀ’s disease: – Vitamin deﬁciency due to alcoholism (thiamine) – Severe retrograde & anterograde – Gradual onset (hard to study ret. & ant. gradient) – Damage to mediodorsal (MD) thalamus More selec<ve brain damage can produce explicit memory problems (amnesia), also Fig. 9.5 Pt R.B.: damage to CA1 area of hpc (very selec<ve) More selec<ve brain damage can produce explicit memory problems (amnesia), also Korsakoﬀ’s amnesia: damage to MD thalamus (diencephalon area of brain) medial diencephalic amnesia (Korsakoﬀ’s and Pt N.A.) 8 2/25/09 Other causes of amnesia • 3) Pa<ent N.A. : – Fencing foil through MD thalamus – Severe anterograde amnesia (verbal info b/c lang. on lek for him) 4) Alzheimerʼs disease: • More general memory loss • Explicit (ret. & ant.) + implicit...
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- Winter '09