DanielleEndo - October 31, 2008 Happy Halloween! 1969:...

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Unformatted text preview: October 31, 2008 Happy Halloween! 1969: First concrete proof of hormone receptors in target tissues (insulin receptors in liver) 1972: Insulin receptors were first characterized 1973 and 1974: Radioreceptor assays were first developed (for prolactin and growth hormone, respectively) What is the central premise of hormone/receptor interaction? Receptors must be present in a tissue for that tissue to be a hormone target. These receptors are specific to a particular hormone This idea is central to understanding many diseases and also disease treatments. It is possible to regulate a tissues response to a hormone by a competitive inhibitor, or a ligand that binds to the hormone receptor without eliciting a response Also called an antagonist This demonstrates the importance of a receptor: if the receptor cannot respond to a hormone, then the hormone has no effect on target tissues, even if expressed in high concentration. Similarly, an agonist has an opposite effect on hormone receptor activity. An agonist is a molecule that can bind to a specific hormones receptor to elicit the appropriate response This molecule is usually similar in shape to the...
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This note was uploaded on 03/23/2009 for the course ANSCI 1110 taught by Professor Brucecurrie during the Fall '08 term at Cornell University (Engineering School).

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DanielleEndo - October 31, 2008 Happy Halloween! 1969:...

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