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DanielleEndo

DanielleEndo - Happy Halloween 1969 First concrete proof...

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Unformatted text preview: October 31, 2008 Happy Halloween! ¡ 1969: First concrete proof of hormone receptors in target tissues (insulin receptors in liver) ¡ 1972: Insulin receptors were first characterized ¡ 1973 and 1974: Radioreceptor assays were first developed (for prolactin and growth hormone, respectively) What is the central premise of hormone/receptor interaction? ¡ Receptors must be present in a tissue for that tissue to be a hormone target. ¡ These receptors are specific to a particular hormone ¡ This idea is central to understanding many diseases and also disease treatments. • It is possible to regulate a tissue’s response to a hormone by a competitive inhibitor, or a ligand that binds to the hormone receptor without eliciting a response – Also called an antagonist • This demonstrates the importance of a receptor: if the receptor cannot respond to a hormone, then the hormone has no effect on target tissues, even if expressed in high concentration. ¡ Similarly, an agonist has an opposite effect on hormone receptor activity. ¡ An agonist is a molecule that can bind to a specific hormone’s receptor to elicit the appropriate response ¡ This molecule is usually similar in shape to the...
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DanielleEndo - Happy Halloween 1969 First concrete proof...

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