Ellen- presentation on hormone receptors

Ellen- presentation on hormone receptors - Hormone...

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Hormone Receptors: Explaining and Treating Endocrinopathies Animal Science 1100 October 31, 2008
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Endocrinopathies • Disease or condition resulting from the dysfunction of an endocrine gland • Associated with every endocrine gland and most hormones in the body. • Can be explained and understood using knowledge of hormone actions and receptors.
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Laron-type Dwarfism • Form of human dwarfism: extreme growth retardation • Most types of dwarfism respond to treatment with growth hormone (GH), but Laron-type dwarfism does not • Found to result from a complete absence of receptors for growth hormone or mutations in the receptors that prevent proper binding of GH or activation of the signal transduction pathway • Lack of receptors or problems with the receptors means the tissues will not respond to the hormone, no matter how large the dose • Other types of dwarfism result from inadequate secretion or absence of GH, so they have receptors and respond to GH injections • Treatment with IGF-1 has been found to be effective
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Thyroid abnormalities • Hyperthyroidism – Over-production of thyroid hormones T3 and T4 leads to increased metabolism – Common in aging cats – Symptoms: • Weight loss • Rapid heart rate • Increased appetite • Nervousness • Enlarged thyroid glad • Fatigue • Increased sensitivity to heat •H y p o t h y r o i d i s m – Underactive thyroid gland causes decreased metabolism – Common in older dogs – Symptoms: • Fatigue • Increased sensitivity to cold • Weight gain – May result from treatment for hyperthyroidism – Can also be caused by iodine deficiency
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Grave’s Disease • Extreme hyper thyroidism • Due to receptors for thyroid stimulating hormone (TSH) in the thyroid being occupied and continuously stimulated by auto-antibodies against the receptor • Auto-antibodies are produced by the body and mimic TSH to bind to the receptors • Occupation of these receptors stimulates them, resulting in over-production of hormones by the thyroid gland • One symptom is goiter, or enlargement of the thyroid gland
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Sheep with goiter Enlarged thyroid gland
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This note was uploaded on 03/23/2009 for the course ANSCI 1110 taught by Professor Brucecurrie during the Fall '08 term at Cornell University (Engineering School).

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Ellen- presentation on hormone receptors - Hormone...

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