CH.4 part2

CH.4 part2 - Psychopharmacology Ch. 4 (continued) Sites of...

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Psychopharmacology Ch. 4 (continued)
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Two Generalized Actions 1. Agonist : A drug that facilitates the effects of a particular neurotransmitter on the post-synaptic cell. 2. Antagonist : A drug that opposes or inhibits the effects of a particular neurotransmitter on the postsynaptic cell Sites of Drug Actions Neurotransmitter EPSP Agonist More EPSP Neurotransmitter IPSP Agonist More IPSP Neurotransmitter EPSP Antagonist Less EPSP Neurotransmitter IPSP Antagonist Less IPSP
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Competitive Binding : Drug competes with neurotransmitter to bind at the neurotransmitter binding site on the post synaptic membrane. Direct Agonist : facilitates neurotransmitter postsynaptic actions Direct Antagonist : hinders neurotransmitter postsynaptic actions Noncompetitive Binding : Drug binds to a site on a receptor but does NOT interfere with neurotransmitter binding to binding site Indirect Agonist: Drug facilitates neurotransmitter action (without interfering with neurotransmitter binding site) Indirect Antagonist : Drug hinders neurotransmitter action (without interfering with neurotransmitter binding site) Targets & Effects of Drugs on Receptors
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Neurotransmitter Drug A Direct Agonist Drug B Direct Antagonist Competitive Binding Example of Competitive Binding Determine Postsynaptic effect of Neurotransmitter First EPSP EPSP No effect or less EPSP Drug A Drug B Agonist Antagonist
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Neurotransmitter Drug A Direct Agonist Drug B Direct Antagonist Competitive Binding Example of Competitive Binding Determine Postsynaptic effect of Neurotransmitter First IPSP IPSP No effect or less IPSP
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Example of Noncompetitive Binding Determine Postsynaptic effect of Neurotransmitter First EPSP EPSP No effect or less EPSP Drug A Drug B Agonist Antagonist
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This note was uploaded on 03/24/2009 for the course PGS 24674 taught by Professor Biswas during the Spring '09 term at ASU.

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CH.4 part2 - Psychopharmacology Ch. 4 (continued) Sites of...

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