Ch5 - Techniques in Physiological Psychology Ch 5 Know All...

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Unformatted text preview: Techniques in Physiological Psychology Ch. 5 Know All Definitions In Lower Right Corner of Book and… • Purpose of a technique (why is the technique used)? • Method to accomplish goals (be able to describe the procedure). Methods and Strategies of Research 1. Experimental Ablation 2. Neurochemical Methods 3. Recording and Stimulating Neural Activity 4. Genetic Methods A. Goal: To place an electrode or cannula within the brain. Reason: To alter a part/nuclei of the brain using surgical, chemical or electrical means to find it’s function. Stereotaxic Surgery : brain surgery using a stereotaxic apparatus to position an electrode or cannula in a specified position in the depth of the brain. Stereotaxic apparatus : a device that permits a surgeon to position an electrode or cannula into a specific part of the brain. These are usually brain regions that are not on the surface and thus, cannot be directly observed. Stereotaxic atlas : A collection of drawings/illustrations of the brain of a particular animal with measurements that provide coordinates for stereotaxic surgery. Experimental Ablation Stereotaxic Surgery in Rodents Fig. 5.5 Stereotaxic Surgery 1. Identify the target brain structure 2. Determine its three-dimensional coordinates: a. anterior-posterior (AP) x-axis b. medial lateral (ML) y-axis c. dorsal ventral (DV) z-axis 3. First, determine Bregma distance. Fig 5.3 Bregma is the junction of the sagittal and coronal sutures of the skull: often used as a reference point for stereotaxic brain surgery. Location of Bregma Coronal Section of Brain Missed target Captured target Fig. 3.2 Bregma = -2 Identify Coronal Section with Target Within The Same Plane Bregma = 0 (too far anterior) Bregma = + 3 (still too far anterior) Bregma = -2 (just right) Dorsal view Sagittal/side view Fig. 5.3 Stereotaxic Surgery 1 2 3 4 5 6 7 5 6 7 8 9 1 2 3 4 Anterior-Posterior= look at coronal section from bregma (last slide = -2) Medial-Lateral = 1 Dorsal-Ventral = 6.5 Fig. 5.4 Stereotaxic Surgery in Humans Fig. 5.6 B. Goal: To Lesion or inactivate parts of the brain 1. Radiofrequency or Electrolytic Lesion : lesion produced by passing electrical current Types of lesions (Fig. 5.1) 3V MPN Disadvantage: Kills both neuronal cell bodies and axons in the vicinity. 2. Excitotoxic Lesion2....
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This note was uploaded on 03/24/2009 for the course PGS 24674 taught by Professor Biswas during the Spring '09 term at ASU.

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Ch5 - Techniques in Physiological Psychology Ch 5 Know All...

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